International journal of dermatology · 2006
Treatment of diffuse cutaneous leishmaniasis with miltefosine: a case report.
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Zerpa Olga, Blanco Belkys, Kannee Carmen, Ulrich Marian, Sindermann Herbert, Engel Juergen, Convit Jacinto
Аннотация
BACKGROUND: A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial repercussions and no effective treatment at present, was treated with miltefosine.
METHODS: The patient was treated for 120 days, 100 mg/day for 1 week, then 150 mg/day subsequently.
RESULTS: Lesions were free of parasites at 43 days, and no signs of infiltration were present at day 76. No adverse side effects were observed.
CONCLUSIONS: The dramatic clinical effect of miltefosine in this patient appears to fully justify further evaluation of this experimental therapy in DCL.
METHODS: The patient was treated for 120 days, 100 mg/day for 1 week, then 150 mg/day subsequently.
RESULTS: Lesions were free of parasites at 43 days, and no signs of infiltration were present at day 76. No adverse side effects were observed.
CONCLUSIONS: The dramatic clinical effect of miltefosine in this patient appears to fully justify further evaluation of this experimental therapy in DCL.