Atherosclerosis · 2026
Urinary orosomucoid and the risk of cardiovascular events and all-cause mortality in the general population. The Tromsø Study 2007-2021.
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Andreassen Runa M, Melsom Toralf, Løchen Maja-Lisa, Wilsgaard Tom, Mathiesen Ellisiv B, Brobak Karl M, Solbu Marit D
Аннотация
BACKGROUND: Urinary orosomucoid may reflect inflammation and endothelial dysfunction and has been linked to subclinical cardiovascular disease in selected populations. Its prognostic value in the general population remains uncertain. We hypothesised that an elevated urinary orosomucoid-to-creatinine ratio (UOCR) is independently associated with the risk of myocardial infarction (MI), ischaemic stroke, and all-cause mortality.
METHODS: We included participants from the population-based Tromsø Study (2007-2008) without prior MI or ischaemic stroke at baseline. Urinary orosomucoid was measured from three urine samples and expressed as UOCR (mg/mmol). Cox proportional hazard models were used to assess associations with incident MI, ischaemic stroke, and all-cause mortality, adjusting for traditional cardiovascular risk factors and urinary albumin-to-creatinine ratio. Analyses included sex-specific models and interaction testing.
RESULTS: In total, 6607 participants (3911 women and 2696 men; mean age 63 ± 9 years) were included and followed for a median of 13.2 years. During follow-up, 488 participants experienced MI, 385 had ischaemic stroke, and 1251 died. Elevated UOCR was associated with increased risk of all outcomes. Comparing highest with lowest quartiles, UOCR predicted MI (HR 1.45, 95% CI 1.09-1.92, p = 0.01), ischaemic stroke (HR 2.34, 95% CI 1.67-3.28, p < 0.001), and all-cause mortality (HR 1.72, 95% CI 1.43-2.08, p < 0.001) in fully adjusted models. In sex-specific analyses, the association with MI was stronger in women than in men (p for interaction = 0.002).
CONCLUSION: UOCR is independently associated with the risk of MI, ischaemic stroke, and all-cause mortality in the general population; however, its clinical utility remains to be established.
METHODS: We included participants from the population-based Tromsø Study (2007-2008) without prior MI or ischaemic stroke at baseline. Urinary orosomucoid was measured from three urine samples and expressed as UOCR (mg/mmol). Cox proportional hazard models were used to assess associations with incident MI, ischaemic stroke, and all-cause mortality, adjusting for traditional cardiovascular risk factors and urinary albumin-to-creatinine ratio. Analyses included sex-specific models and interaction testing.
RESULTS: In total, 6607 participants (3911 women and 2696 men; mean age 63 ± 9 years) were included and followed for a median of 13.2 years. During follow-up, 488 participants experienced MI, 385 had ischaemic stroke, and 1251 died. Elevated UOCR was associated with increased risk of all outcomes. Comparing highest with lowest quartiles, UOCR predicted MI (HR 1.45, 95% CI 1.09-1.92, p = 0.01), ischaemic stroke (HR 2.34, 95% CI 1.67-3.28, p < 0.001), and all-cause mortality (HR 1.72, 95% CI 1.43-2.08, p < 0.001) in fully adjusted models. In sex-specific analyses, the association with MI was stronger in women than in men (p for interaction = 0.002).
CONCLUSION: UOCR is independently associated with the risk of MI, ischaemic stroke, and all-cause mortality in the general population; however, its clinical utility remains to be established.