Studies on the efficacy of DL-alpha-difluoromethylornithine (DFMO) associated with bleomycin and suramin for treatment of mice infected with metacyclic forms of Trypanosoma brucei brucei.

NMRI mice were treated with DFMO-bleomycin and DFMO-suramin drug combinations at day 8 post-inoculation. The highest percentage of parasitologically non patent mice were attained with DFMO-suramin combination treatments. Parasitological and serological examinations of the non-relapsing mice strongly suggests trypanosome clearance.