The ventricular ependyma of mice infected with Trypanosoma brucei.

The fine structure of ependymal cells lining the cerebral ventricles of normal mice and of mice infected with Trypanosoma brucei was examined by transmission electron microscopy. Most of the ependymal cells had been stripped from the ventricular surface of the brain in infected animals but some of the remaining ependymal cells contained intracellular trypomastigotes. The same process of stripping had occurred in a single human brain that was included in the series, but intracellular forms were not found. The significance of the intracellular forms and the implication of the stripping of ventricular ependymal cells are discussed in relation to the pathogenesis of sleeping sickness.