Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
Test-retest measurement properties of the MScanFit method for motor unit number estimation in individuals with Amyotrophic Lateral Sclerosis.
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Arora Tarun, Thorgersen Jørn Klepp, Jones Kelvin Edward, Allen Sara Maria, Schulze Daniel Gregor, Dunker Øystein, Tankisi Hatice, Nilsen Kristian Bernhard
Аннотация
OBJECTIVE: MScanFit is one of the Motor Unit Number Estimation (MUNE) methods considered as a potential biomarker for Amyotrophic Lateral Sclerosis (ALS) diagnosis and clinical trials. We investigated the test-retest measurement properties of MScanFit across multiple muscles in individuals with ALS.
METHODS: We recorded MUNE from Abductor Pollicis Brevis (APB), Abductor Digiti Minimi (ADM), and Tibialis Anterior (TA) muscles in seventeen adults with ALS separated by 1-2 weeks. Intraclass correlation and concordance correlation coefficients provided reliability estimates. Overall agreement was evaluated using pairedt-tests or the Wilcoxon signed-rank test and an estimation statistical approach. The standard error of measurement and the smallest detectable change provided the extent of agreement.
RESULTS: The reliability coefficients ranged from 0.66 to 0.91. The measurement error was high (standard error of measurement > 10 %). The smallest detectable change was high (24-61 units) at an individual level, although smaller (∼10 units) at a group level (N = 10-30) CONCLUSION: MScanFit has moderate-to-excellent reliability and can reliably detect smaller changes at a group level, but is limited in reliably detecting smaller changes at an individual level.
SIGNIFICANCE: The MScanFit MUNE can potentially serve as a group-level biomarker in ALS clinical trials.
METHODS: We recorded MUNE from Abductor Pollicis Brevis (APB), Abductor Digiti Minimi (ADM), and Tibialis Anterior (TA) muscles in seventeen adults with ALS separated by 1-2 weeks. Intraclass correlation and concordance correlation coefficients provided reliability estimates. Overall agreement was evaluated using pairedt-tests or the Wilcoxon signed-rank test and an estimation statistical approach. The standard error of measurement and the smallest detectable change provided the extent of agreement.
RESULTS: The reliability coefficients ranged from 0.66 to 0.91. The measurement error was high (standard error of measurement > 10 %). The smallest detectable change was high (24-61 units) at an individual level, although smaller (∼10 units) at a group level (N = 10-30) CONCLUSION: MScanFit has moderate-to-excellent reliability and can reliably detect smaller changes at a group level, but is limited in reliably detecting smaller changes at an individual level.
SIGNIFICANCE: The MScanFit MUNE can potentially serve as a group-level biomarker in ALS clinical trials.