The journal of vascular access · 2013
Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis.
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Roy-Chaudhury Prabir, Khan Rao, Campos Begoña, Wang Yang, Kurian Michelle, Lee Timmy, Arend Lois, Munda Rino
Аннотация
PURPOSE: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies.
METHODS: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis.
RESULTS: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d.
CONCLUSION: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.
METHODS: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis.
RESULTS: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d.
CONCLUSION: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.