Meningiomas in young cats with mucopolysaccharidosis I.

Meningiomas are the most common central nervous system tumor of the cat, with an age at diagnosis of greater than nine years in 73% of the affected animals. Four of seven cats with alpha-L-iduronidase deficient mucopolysaccharidosis I had meningiomas at postmortem examination. All four cats were less than three years of age. The relationship between the meningiomas and the metabolic defect of MPS I is not clear.