European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2022
In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery.
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Nižić Nodilo Laura, Perkušić Mirna, Ugrina Ivo, Špoljarić Drago, Jakobušić Brala Cvijeta, Amidžić Klarić Daniela, Lovrić Jasmina, Saršon Vesna, Safundžić Kučuk Maša, Zadravec Dijana, Kalogjera Livije, Pepić Ivan, Hafner Anita
Аннотация
In this work we present the development of in situ gelling nanosuspension as advanced form for fluticasone propionate nasal delivery. Drug nanocrystals were prepared by wet milling technique. Incorporation of drug nanocrystals into polymeric in situ gelling system with pectin and sodium hyaluronate as constitutive polymers was fine-tuned attaining appropriate formulation surface tension, viscosity and gelling ability. Drug nanonisation improved the release profile and enhanced formulation mucoadhesive properties. QbD approach combining formulation and administration parameters resulted in optimised nasal deposition profile, with 51.8% of the dose deposited in the middle meatus, the critical region in the treatment of rhinosinusitis and nasal polyposis. Results obtained in biocompatibility and physico-chemical stability studies confirmed the leading formulation potential for safe and efficient nasal corticosteroid delivery.