Cerebral cortex (New York, N.Y. : 1991) · 2017
Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Hilal Muna L, Moreau Maité M, Racca Claudia, Pinheiro Vera L, Piguel Nicolas H, Santoni Marie-Josée, Dos Santos Carvalho Steve, Blanc Jean-Michel, Abada Yah-Se K, Peyroutou Ronan, Medina Chantal, Doat Hélène, Papouin Thomas, Vuillard Laurent, Borg Jean-Paul, Rachel Rivka, Panatier Aude, Montcouquiol Mireille, Oliet Stéphane H R, Sans Nathalie
Аннотация
Planar cell polarity (PCP) signaling is well known to play a critical role during prenatal brain development; whether it plays specific roles at postnatal stages remains rather unknown. Here, we investigated the role of a key PCP-associated gene scrib in CA1 hippocampal structure and function at postnatal stages. We found that Scrib is required for learning and memory consolidation in the Morris water maze as well as synaptic maturation and NMDAR-dependent bidirectional plasticity. Furthermore, we unveiled a direct molecular interaction between Scrib and PP1/PP2A phosphatases whose levels were decreased in postsynaptic density of conditional knock-out mice. Remarkably, exposure to enriched environment (EE) preserved memory formation in CaMK-Scrib-/- mice by recovering synaptic plasticity and maturation. Thus, Scrib is required for synaptic function involved in memory formation and EE has beneficiary therapeutic effects. Our results demonstrate a distinct new role for a PCP-associated protein, beyond embryonic development, in cognitive functions during adulthood.