Ethical and Jurisprudential Considerations of Stem Cell Donation in the Gulf.

Stem cell donation has become an important component of contemporary regenerative medicine, particularly in the treatment of hematological malignancies, immune deficiencies, genetic disorders, and selected metabolic diseases. However, its implementation in Muslim Gulf societies remains shaped by medical awareness, legal clarity, institutional readiness, and religious -ethical considerations. In this study, we examined community and physician perspectives on stem cell donation in the Gulf Cooperation Council context, with particular attention to Islamic jurisprudence, ethical values, and regulatory frameworks. We adopted an integrative design, combining doctrinal legal and jurisprudential analysis with 2 cross -sectional surveys. The community survey included 65 participants and examined awareness, perceived barriers, religious considerations, registration intention, and willingness to donate. The physician survey included 55 medical doctors and assessed professional knowledge, perceived therapeutic importance, institutional support, legal awareness, and policy preferences. Findings showed that both community members and physicians recognized the humanitarian and therapeutic value of stem cell donation, yet this positive perception had not translated into active registration or strong system -level engagement. Among community participants, lack of information, uncertainty regarding religious rulings, and limited awareness of registration mechanisms emerged as key barriers. Among physicians, limited familiarity with legal frameworks and inadequate institutional support were central constraints. Strengthening stem cell donation in the Gulf Cooperation Council requires coordinated educational initiatives, clear religious guidance, stronger institutional training, and legally transparent opt -in donation systems that respect cultural, ethical, and religious sensitivities.