Age-related changes in hemodynamics affecting valve performance.

Degenerative processes result in changes in both the aortic and mitral valves. For example, degenerative changes may lead to significant aortic stenosis or myxomatous mitral valves. Flows through each valve are determined not only by the properties of the valve itself, but also by the properties of proximal and distal chambers, which also undergo changes with age and diseases associated with the elderly, such as hypertension and coronary artery disease. Assessment of valvular performance should consider the effects of atrial-ventricular coupling (for the mitral valve) or ventricular-arterial coupling (for the aortic valve). Design of therapy or intervention should accordingly consider effects on the system as a whole.