Acta oto-laryngologica · 2019
Oncological outcomes of surgical treatment for T3 supraglottic laryngeal squamous cell carcinoma patients.
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Zhou Jian, Zhou Liang, Tao Lei, Zhang Ming, Wu Haitao, Chen Xiaoling, Li Xiaoming, Li Cai, Gong Hongli
Аннотация
BACKGROUND: T3 supraglottic laryngeal carcinoma (LC) is a common advanced laryngeal cancer.
OBJECTIVE: This study was conducted to assess the clinical results of pathological T3 (pT3) supraglottic LC patients who were amenable to laryngectomy treated with primary surgery and postoperative therapy.
METHODS: Retrospective review of 202 pT3 cases of supraglottic laryngeal squamous cell carcinoma.
RESULTS: The five-year cancer specific survival (CSS) rate was 63.7% and the overall survival rate (OS) was 62.8%. For T3 supraglottic patients who underwent total laryngectomy, the five-year disease-free survival (DFS) was 51.8%, and the CSS was 62.5%. For patients who underwent partial laryngectomy, the five-year DFS was 72.2%, and the CSS was 79.0%. High lymph node and stage status are predictors of mortality for these patients. No difference was found in the DFS and CSS rates between patients with negative margins and those with positive margins following postoperative radiotherapy and chemotherapy.
CONCLUSION: Surgical treatment of T3 supraglottic LC patients achieved satisfactory results. Postoperative radiotherapy and chemotherapy are an effective method of treatment for T3 supraglottic LC patients, especially for those with a positive margin.
OBJECTIVE: This study was conducted to assess the clinical results of pathological T3 (pT3) supraglottic LC patients who were amenable to laryngectomy treated with primary surgery and postoperative therapy.
METHODS: Retrospective review of 202 pT3 cases of supraglottic laryngeal squamous cell carcinoma.
RESULTS: The five-year cancer specific survival (CSS) rate was 63.7% and the overall survival rate (OS) was 62.8%. For T3 supraglottic patients who underwent total laryngectomy, the five-year disease-free survival (DFS) was 51.8%, and the CSS was 62.5%. For patients who underwent partial laryngectomy, the five-year DFS was 72.2%, and the CSS was 79.0%. High lymph node and stage status are predictors of mortality for these patients. No difference was found in the DFS and CSS rates between patients with negative margins and those with positive margins following postoperative radiotherapy and chemotherapy.
CONCLUSION: Surgical treatment of T3 supraglottic LC patients achieved satisfactory results. Postoperative radiotherapy and chemotherapy are an effective method of treatment for T3 supraglottic LC patients, especially for those with a positive margin.
Предметные рубрики MeSH
AdultAgedCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleGlottisHumansKaplan-Meier EstimateLaryngeal NeoplasmsLaryngectomyMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingPrognosisProportional Hazards ModelsRetrospective StudiesSurvival AnalysisTreatment Outcome