[Role of increase in permeability and circulatory failure in the development of organ dysfunction in severe acute pancreatitis].

Although many factors such as histamine, bradykinin, TNFalpha, IL-1, FDP, thrombin, and PAF are involved in the increase of the vascular permeability, neutrophil infiltration is a major cause of microcirculatory impairment and organ failure in acute pancreatitis. Vasospasm and microthrombi formation due to hypercoagulability are also other cause of deterioration of the microcirculation of the pancreas leading to pancreatic necrosis.