European archives of psychiatry and clinical neuroscience · 2022

Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses.

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Kalman Janos L, Yoshida Tomoya, Andlauer Till F M, Schulte Eva C, Adorjan Kristina, Alda Martin, Ardau Raffaela, Aubry Jean-Michel, Brosch Katharina, Budde Monika, Chillotti Caterina, Czerski Piotr M, DePaulo Raymond J, Forstner Andreas, Goes Fernando S, Grigoroiu-Serbanescu Maria, Grof Paul, Grotegerd Dominik, Hahn Tim, Heilbronner Maria, Hasler Roland, Heilbronner Urs, Heilmann-Heimbach Stefanie, Kapelski Pawel, Kato Tadafumi, Kohshour Mojtaba Oraki, Meinert Susanne, Meller Tina, Nenadić Igor, Nöthen Markus M, Novak Tomas, Opel Nils, Pawlak Joanna, Pfarr Julia-Katharina, Potash James B, Reich-Erkelenz Daniela, Repple Jonathan, Richard-Lepouriel Hélène, Rietschel Marcella, Ringwald Kai G, Rouleau Guy, Schaupp Sabrina, Senner Fanny, Severino Giovanni, Squassina Alessio, Stein Frederike, Stopkova Pavla, Streit Fabian, Thiel Katharina, Thomas-Odenthal Florian, Turecki Gustavo, Twarowska-Hauser Joanna, Winter Alexandra, Zandi Peter P, Kelsoe John R, Consortium on Lithium Genetics (ConLiGen), PsyCourse, Falkai Peter, Dannlowski Udo, Kircher Tilo, Schulze Thomas G, Papiol Sergi

Аннотация

Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.

Предметные рубрики MeSH

Humans Suicidal Ideation Major Depressive Disorder Mental Health Personality Phenotype

Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH