Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Cele Sandile, Jackson Laurelle, Khoury David S, Khan Khadija, Moyo-Gwete Thandeka, Tegally Houriiyah, San James Emmanuel, Cromer Deborah, Scheepers Cathrine, Amoako Daniel G, Karim Farina, Bernstein Mallory, Lustig Gila, Archary Derseree, Smith Muneerah, Ganga Yashica, Jule Zesuliwe, Reedoy Kajal, Hwa Shi-Hsia, Giandhari Jennifer, Blackburn Jonathan M, Gosnell Bernadett I, Abdool Karim Salim S, Hanekom Willem, NGS-SA, COMMIT-KZN Team, von Gottberg Anne, Bhiman Jinal N, Lessells Richard J, Moosa Mahomed-Yunus S, Davenport Miles P, de Oliveira Tulio, Moore Penny L, Sigal Alex
Аннотация
The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of previous infection. We isolated and sequence-confirmed live Omicron virus from an infected person and observed that Omicron requires the angiotensin-converting enzyme 2 (ACE2) receptor to infect cells. We compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain and found that neutralization of ancestral virus was much higher in infected and vaccinated individuals compared with the vaccinated-only participants. However, both groups showed a 22-fold reduction in vaccine-elicited neutralization by the Omicron variant. Participants who were vaccinated and had previously been infected exhibited residual neutralization of Omicron similar to the level of neutralization of the ancestral virus observed in the vaccination-only group. These data support the notion that reasonable protection against Omicron may be maintained using vaccination approaches.