Endocrine development · 2005
IGFs and IGFBPs in adult growth hormone deficiency.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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Aimaretti Gianluca, Baldelli Roberto, Corneli Ginevra, Croce Chiara, Rovere Silvia, Baffoni Claudia, Bellone Simonetta, Gasco SValentina, Granata Riccarda, Grottoli Silvia, Ghigo Ezio
Аннотация
In the current guidelines for the diagnosis of adult GH deficiency (GHD) it is stated that, within the appropriate clinical context, it has to be shown by provocative tests only. But the diagnostic value of measuring IGF-I levels has been recently revisited. It has been confirmed that normal IGF-I levels do not rule out severe GHD in adults. However, it has also been emphasized that very low IGF-I levels in patients highly suspected for GHD (and without malnutrition, liver disease or hypothyroidism) could be considered definite evidence for severe GHD. This assumption particularly applies to patients with childhood-onset, severe GHD or with multiple hypopituitarism acquired in adulthood. The value of measuring IGF-I levels for monitoring the efficacy and the adequacy of rhGH replacement remains definitely accepted.