Scientific reports · 2024
Identifying plasma proteomic signatures from health to heart failure, across the ejection fraction spectrum.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Andrzejczyk Karolina, Abou Kamar Sabrina, van Ommen Anne-Mar, Canto Elisa Dal, Petersen Teun B, Valstar Gideon, Akkerhuis K Martijn, Cramer Maarten Jan, Umans Victor, Rutten Frans H, Teske Arco, Boersma Eric, Menken Roxana, van Dalen Bas M, Hofstra Leonard, Verhaar Marianne, Brugts Jasper, Asselbergs Folkert, den Ruijter Hester, Kardys Isabella
Аннотация
Circulating proteins may provide insights into the varying biological mechanisms involved in heart failure (HF) with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). We aimed to identify specific proteomic patterns for HF, by comparing proteomic profiles across the ejection fraction spectrum. We investigated 4210 circulating proteins in 739 patients with normal (Stage A/Healthy) or elevated (Stage B) filling pressures, HFpEF, or ischemic HFrEF (iHFrEF). We found 2122 differentially expressed proteins between iHFrEF-Stage A/Healthy, 1462 between iHFrEF-HFpEF and 52 between HFpEF-Stage A/Healthy. Of these 52 proteins, 50 were also found in iHFrEF vs. Stage A/Healthy, leaving SLITRK6 and NELL2 expressed in lower levels only in HFpEF. Moreover, 108 proteins, linked to regulation of cell fate commitment, differed only between iHFrEF-HFpEF. Proteomics across the HF spectrum reveals overlap in differentially expressed proteins compared to stage A/Healthy. Multiple proteins are unique for distinguishing iHFrEF from HFpEF, supporting the capacity of proteomics to discern between these conditions.