American heart journal plus : cardiology research and practice · 2026
Outcomes of isolated ostial LAD PCI versus multivessel PCI including ostial LAD lesions.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ntantou Eleni, Camilleri William, Daemen Joost, Diletti Roberto, Wilschut Jeroen, Kardys Isabella, Nuis Rutger-Jan, van Mieghem Nicolas M, den Dekker Wijnand K
Аннотация
BACKGROUND: Ostial lesions of the left anterior descending (LAD) coronary artery are critical targets for revascularization due to their role in supplying a large portion of the myocardium, and are often accompanied by multivessel disease, complicating treatment planning and prognosis.
METHODS: This was a retrospective, single-center study. Patients with ostial LAD PCI isolated or in conjunction with PCI in another vessel were included and were grouped into isolated ostial LAD PCI (n = 276) or multivessel PCI including ostial LAD PCI (n = 218). The primary endpoint was major adverse cardiovascular events (MACE) defined by a composite of all-cause mortality, myocardial infarction, stroke, or unplanned repeat revascularization.
RESULTS: Participants undergoing multivessel PCI were significantly older, with a median age of 70 years (IQR: 62-77), compared to 68 years (IQR: 59-75) in the isolated ostial LAD PCI group (p = 0.036). The sex distribution was similar between groups, with females comprising 26.6% of the multivessel PCI group and 28.6% of the isolated ostial LAD group (p = 0.619). At a median follow-up of 756 days (IQR: 433-1165), the incidence of MACE was comparable between groups, occurring in 28.4% of the multivessel PCI group versus 25.4% in the isolated ostial LAD PCI group (adjusted HR 1.04; 95% CI 0.73-1.48; p = 0.81).
CONCLUSION: In patients undergoing ostial LAD PCI, treatment of an additional vessel did not increase the risk of MACE in long-term follow-up.
METHODS: This was a retrospective, single-center study. Patients with ostial LAD PCI isolated or in conjunction with PCI in another vessel were included and were grouped into isolated ostial LAD PCI (n = 276) or multivessel PCI including ostial LAD PCI (n = 218). The primary endpoint was major adverse cardiovascular events (MACE) defined by a composite of all-cause mortality, myocardial infarction, stroke, or unplanned repeat revascularization.
RESULTS: Participants undergoing multivessel PCI were significantly older, with a median age of 70 years (IQR: 62-77), compared to 68 years (IQR: 59-75) in the isolated ostial LAD PCI group (p = 0.036). The sex distribution was similar between groups, with females comprising 26.6% of the multivessel PCI group and 28.6% of the isolated ostial LAD group (p = 0.619). At a median follow-up of 756 days (IQR: 433-1165), the incidence of MACE was comparable between groups, occurring in 28.4% of the multivessel PCI group versus 25.4% in the isolated ostial LAD PCI group (adjusted HR 1.04; 95% CI 0.73-1.48; p = 0.81).
CONCLUSION: In patients undergoing ostial LAD PCI, treatment of an additional vessel did not increase the risk of MACE in long-term follow-up.