Clinical & experimental optometry · 2026
Identifying potential drug targets for seborrhoeic dermatitis and dry eye syndrome through mendelian randomisation analysis.
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Zuo Haihong, Zhou Shuhui, Feng Zuojing
Аннотация
CLINICAL RELEVANCE: Patients with seborrhoeic dermatitis frequently experience comorbid dry eye syndrome, which complicates clinical management. Identifying shared drug targets is a promising strategy for developing novel therapies that concurrently address both conditionggs.
BACKGROUND: Ocular involvement is common in seborrhoeic dermatitis and frequently leads to dry eye syndrome, underscoring the importance of identifying shared drug targets for dual-pathway therapy.
METHODS: A two-sample Mendelian Randomisation (MR) analysis was conducted to identify potential drug targets. Sensitivity and colocalization analyses were performed to confirm shared targets. External replication and summary-data-based MR were used to validate target accuracy. Gene enrichment analysis and drug prediction were employed to explore functional pathways and potential therapeutics.
RESULTS: MR analysis revealed 65 plasma proteins causally associated with seborrhoeic dermatitis (P < 0.05) and 68 with dry eye syndrome (P < 0.05). Colocalization and external replication demonstrated that KRT5 exhibited significant positive causal associations with both seborrhoeic dermatitis (OR = 1.535, 95%CI: 1.092-2.159, P = 0.014) and dry eye syndrome (OR = 2.219, 95%CI: 1.267-3.887, P = 0.005). Gene enrichment analysis indicated that target genes were primarily involved in keratinisation pathways. Drug prediction identified imipenem monohydrate as a potential therapeutic candidate.
CONCLUSION: KRT5 is identified as a promising drug target for both conditions, with imipenem monohydrate as a potential treatment. These findings provide novel therapeutic avenues.
BACKGROUND: Ocular involvement is common in seborrhoeic dermatitis and frequently leads to dry eye syndrome, underscoring the importance of identifying shared drug targets for dual-pathway therapy.
METHODS: A two-sample Mendelian Randomisation (MR) analysis was conducted to identify potential drug targets. Sensitivity and colocalization analyses were performed to confirm shared targets. External replication and summary-data-based MR were used to validate target accuracy. Gene enrichment analysis and drug prediction were employed to explore functional pathways and potential therapeutics.
RESULTS: MR analysis revealed 65 plasma proteins causally associated with seborrhoeic dermatitis (P < 0.05) and 68 with dry eye syndrome (P < 0.05). Colocalization and external replication demonstrated that KRT5 exhibited significant positive causal associations with both seborrhoeic dermatitis (OR = 1.535, 95%CI: 1.092-2.159, P = 0.014) and dry eye syndrome (OR = 2.219, 95%CI: 1.267-3.887, P = 0.005). Gene enrichment analysis indicated that target genes were primarily involved in keratinisation pathways. Drug prediction identified imipenem monohydrate as a potential therapeutic candidate.
CONCLUSION: KRT5 is identified as a promising drug target for both conditions, with imipenem monohydrate as a potential treatment. These findings provide novel therapeutic avenues.