Journal of computer assisted tomography · 2026
Accuracy and Variability of Spatial Localization of Infarct Core Predicted by CT Perfusion.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Berglar Inka K, Moser Levin M, Kamalian Shervin, Vranic Justin, Kamalian Shahmir, Payabvash Sam, Khalid Rehab N, Patel Aman, Stapleton Christopher, Singhal Aneesh B, Rost Natalia S, Gonzalez Ramon G, Schaefer Pamela W, Lev Michael H, Regenhardt Robert W, Gupta Rajiv
Аннотация
OBJECTIVE: In patients with acute ischemic stroke, CT perfusion (CTP)-derived infarct core is valuable for prognostication, triage and transfer decision-making, and for informing studies of emerging therapeutic targets. In this study, we compare the accuracy and variability of the infarct core predicted by 2 FDA-cleared CTP programs, using diffusion-weighted MRI (DWI) as the reference standard.
METHODS: We analyzed 61 stroke patients who underwent admission CTP and DWI within 90 minutes. Infarct core was estimated using relative cerebral blood flow thresholds and compared with DWI-derived ground truth. After coregistration of CTP and DWI, Dice similarity coefficients were calculated to quantify the topographic concordance of the infarct core.
RESULTS: The CTP-determined infarct core volumes were significantly correlated with DWI but demonstrated substantial variability and bias. Our results showed limited topographic overlap, with median dice scores of 0.367 (CTP-A) and 0.289 (CTP-B). However, in patients with larger infarcts (volumes ≥50 mL), CTP provides more reliable estimates of spatial agreement, reaching median Dice scores of 0.61 (CTP-A) and 0.47 (CTP-B).
CONCLUSIONS: Although these findings show a generally low accuracy of CTP estimation, they suggest that CTP may offer clinically meaningful insights for decision-making in the large-core setting and inform the design of future trials.
METHODS: We analyzed 61 stroke patients who underwent admission CTP and DWI within 90 minutes. Infarct core was estimated using relative cerebral blood flow thresholds and compared with DWI-derived ground truth. After coregistration of CTP and DWI, Dice similarity coefficients were calculated to quantify the topographic concordance of the infarct core.
RESULTS: The CTP-determined infarct core volumes were significantly correlated with DWI but demonstrated substantial variability and bias. Our results showed limited topographic overlap, with median dice scores of 0.367 (CTP-A) and 0.289 (CTP-B). However, in patients with larger infarcts (volumes ≥50 mL), CTP provides more reliable estimates of spatial agreement, reaching median Dice scores of 0.61 (CTP-A) and 0.47 (CTP-B).
CONCLUSIONS: Although these findings show a generally low accuracy of CTP estimation, they suggest that CTP may offer clinically meaningful insights for decision-making in the large-core setting and inform the design of future trials.