Diabetes research and clinical practice · 2026
Prospective cohort study of cancer incidence and related factors among patients with type 2 diabetes in Japan.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yoshikawa Atsushi, Okita Kohei, Tsuneda Kazushiro, Fujita Shingo, Takahara Mitsuyoshi, Kozawa Junji, Watanabe Nobuaki, Shimomura Iichiro, Kawata Sumio
Аннотация
AIMS: Type 2 diabetes has been reported to associated with an increased risk of malignant neoplasms; however, the factors influencing cancer development in diabetic patients have not been fully elucidated. Therefore we initiated Nishinomiya Study to investigate the association between diabetes and cancer risk.
METHODS: Participants were 5,210 outpatients receiving treatment for type 2 diabetes enrolled in the Nishinomiya Study. We prospectively investigated the association of baseline clinical characteristics with cancer incidence.
RESULTS: During a mean follow-up period of 4.8 years, 411 participants were newly diagnosed with cancer. Kaplan-Meier analysis demonstrated that cancer incidence was significantly higher in men than in women and in patients with hypertension than in those without hypertension (both p < 0.0001). In contrast, cancer incidence was significantly lower in patients with dyslipidemia than in those without it (p < 0.0001). Cox proportional hazards analysis identified higher age (HR 1.04), male sex (HR 1.58), greater waist circumference (HR 1.02), hypertension (HR 1.40), and absence of dyslipidemia (HR 0.75) as significant predictors of cancer risk (all p < 0.01).
CONCLUSIONS: Sex, age, abdominal obesity, hypertension, and dyslipidemia may have significant influence cancer risk in Japanese patients with type 2 diabetes.
METHODS: Participants were 5,210 outpatients receiving treatment for type 2 diabetes enrolled in the Nishinomiya Study. We prospectively investigated the association of baseline clinical characteristics with cancer incidence.
RESULTS: During a mean follow-up period of 4.8 years, 411 participants were newly diagnosed with cancer. Kaplan-Meier analysis demonstrated that cancer incidence was significantly higher in men than in women and in patients with hypertension than in those without hypertension (both p < 0.0001). In contrast, cancer incidence was significantly lower in patients with dyslipidemia than in those without it (p < 0.0001). Cox proportional hazards analysis identified higher age (HR 1.04), male sex (HR 1.58), greater waist circumference (HR 1.02), hypertension (HR 1.40), and absence of dyslipidemia (HR 0.75) as significant predictors of cancer risk (all p < 0.01).
CONCLUSIONS: Sex, age, abdominal obesity, hypertension, and dyslipidemia may have significant influence cancer risk in Japanese patients with type 2 diabetes.