Developmental cell · 2018
Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Anzi Shira, Stolovich-Rain Miri, Klochendler Agnes, Fridlich Ori, Helman Aharon, Paz-Sonnenfeld Avital, Avni-Magen Nili, Kaufman Elizabeth, Ginzberg Miriam B, Snider Daniel, Ray Saikat, Brecht Michael, Holmes Melissa M, Meir Karen, Avivi Aaron, Shams Imad, Berkowitz Asaf, Shapiro A M James, Glaser Benjamin, Ben-Sasson Shmuel, Kafri Ran, Dor Yuval
Аннотация
Developmental processes in different mammals are thought to share fundamental cellular mechanisms. We report a dramatic increase in cell size during postnatal pancreas development in rodents, accounting for much of the increase in organ size after birth. Hypertrophy of pancreatic acinar cells involves both higher ploidy and increased biosynthesis per genome copy; is maximal adjacent to islets, suggesting endocrine to exocrine communication; and is partly driven by weaning-related processes. In contrast to the situation in rodents, pancreas cell size in humans remains stable postnatally, indicating organ growth by pure hyperplasia. Pancreatic acinar cell volume varies 9-fold among 24 mammalian species analyzed, and shows a striking inverse correlation with organismal lifespan. We hypothesize that cellular hypertrophy is a strategy for rapid postnatal tissue growth, entailing life-long detrimental effects.