Journal of neurologic physical therapy : JNPT · 2025
Blood Flow Restriction Training in People With Parkinson Disease: A Mixed-Methods Feasibility Study.
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Mañago Mark M, Van Valkenburgh Lauren, Boncella Katie, Will Robert, Feuerstein Jeanne, Swink Laura A, Christiansen Cory L
Аннотация
BACKGROUND AND PURPOSE: To determine the feasibility of low-load resistance blood flow restriction training (BFRT) in people with Parkinson disease (PD).
METHODS: This prospective cohort, convergent parallel mixed-methods design investigated the feasibility of 8 weeks of low-load resistance BFRT in people with PD. Feasibility was determined by enrolling 20 participants, ≥80% retention and adherence, and no serious intervention-related adverse events. Semistructured interviews and questionnaires evaluated acceptability and satisfaction. Changes in muscle strength and thickness, mobility, physical activity, and patient-reported outcomes were also assessed.
RESULTS: Sixteen of 20 participants (80%) were retained at the postintervention assessment (68.1 ± 8.6 years old, 44% Female), completing 88% of visits with no serious adverse events. Qualitative analysis identified 3 themes: satisfaction and acceptability, functional capacity changes, and program feedback. Most participants were satisfied (88%), and lack of satisfaction was primarily related to pressure intolerance and exercise specificity. There were improvements in knee extension and ankle plantarflexion strength (18-22%), 30-Second Sit to Stand (+2.2 reps), Timed Up and Go (-2.1 seconds), and 10-Meter Walk Test (0.12 m/s). The average daily step count decreased (-476 steps/day) and sedentary time increased (21 minutes/day). There were minimal changes in elbow extension strength, rectus femoris muscle thickness, Parkinson's Fatigue Scale, and Patient-Specific Functional Scale.
DISCUSSION AND CONCLUSIONS: BFRT was feasible and safe in people with PD, with promising improvements in muscle strength and mobility, warranting a future efficacy study. Clinicians considering BFRT should carefully evaluate tolerance and make sure BFRT aligns with patient goals.
UNLABELLED: Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content available at: http://links.lww.com/JNPT/A539 ).
METHODS: This prospective cohort, convergent parallel mixed-methods design investigated the feasibility of 8 weeks of low-load resistance BFRT in people with PD. Feasibility was determined by enrolling 20 participants, ≥80% retention and adherence, and no serious intervention-related adverse events. Semistructured interviews and questionnaires evaluated acceptability and satisfaction. Changes in muscle strength and thickness, mobility, physical activity, and patient-reported outcomes were also assessed.
RESULTS: Sixteen of 20 participants (80%) were retained at the postintervention assessment (68.1 ± 8.6 years old, 44% Female), completing 88% of visits with no serious adverse events. Qualitative analysis identified 3 themes: satisfaction and acceptability, functional capacity changes, and program feedback. Most participants were satisfied (88%), and lack of satisfaction was primarily related to pressure intolerance and exercise specificity. There were improvements in knee extension and ankle plantarflexion strength (18-22%), 30-Second Sit to Stand (+2.2 reps), Timed Up and Go (-2.1 seconds), and 10-Meter Walk Test (0.12 m/s). The average daily step count decreased (-476 steps/day) and sedentary time increased (21 minutes/day). There were minimal changes in elbow extension strength, rectus femoris muscle thickness, Parkinson's Fatigue Scale, and Patient-Specific Functional Scale.
DISCUSSION AND CONCLUSIONS: BFRT was feasible and safe in people with PD, with promising improvements in muscle strength and mobility, warranting a future efficacy study. Clinicians considering BFRT should carefully evaluate tolerance and make sure BFRT aligns with patient goals.
UNLABELLED: Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content available at: http://links.lww.com/JNPT/A539 ).