Movement disorders clinical practice · 2025
Subtype of the Freezing of Gait and Motor Function in Patients with Parkinson's Disease.
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Sakai Katsuya, Kawasaki Tsubasa, Kim Kichol, Ogawa Jyunya, Yamaguchi Yuya
Аннотация
BACKGROUND: The association between freezing of gait and motor function in Parkinson's disease is variable, and the results suggest the existence of subtypes.
OBJECTIVES: This study aimed to identify the subtypes of freezing of gait and motor function in patients with Parkinson's disease.
METHODS: Sixty-one patients were included. This study assessed motor function using the freezing of gait questionnaire, the Unified Parkinson's Disease Rating Scale Part III. For statistical analyses, we conducted a cluster analysis using the freezing of gait and motor function. Analysis of covariance with age and L-dopa dosing as a covariate was performed for each cluster (P < 0.05).
RESULTS: Cluster 1 (N = 15) had the lowest freezing of gait scores compared to the other clusters, and its motor function scores were lower than those of cluster 3 (N = 9) (P < 0.05). Cluster 2 (N = 37) had moderate freezing of gait scores (vs. cluster 1, P < 0.05), and motor function showed lower scores than cluster 3 (P < 0.05); however, the score was not significantly different from that of cluster 1 (P > 0.05). Cluster 3 had moderate freezing of gait scores (vs. cluster 1, P < 0.05; vs. 2, P > 0.05) and higher motor function scores than the other clusters (P < 0.05); however, the freezing of gait score was not significantly different from that of cluster 2 (P > 0.05).
CONCLUSIONS: This study revealed new subtypes that presents with freezing of gait but high motor function in patients with Parkinson's disease.
OBJECTIVES: This study aimed to identify the subtypes of freezing of gait and motor function in patients with Parkinson's disease.
METHODS: Sixty-one patients were included. This study assessed motor function using the freezing of gait questionnaire, the Unified Parkinson's Disease Rating Scale Part III. For statistical analyses, we conducted a cluster analysis using the freezing of gait and motor function. Analysis of covariance with age and L-dopa dosing as a covariate was performed for each cluster (P < 0.05).
RESULTS: Cluster 1 (N = 15) had the lowest freezing of gait scores compared to the other clusters, and its motor function scores were lower than those of cluster 3 (N = 9) (P < 0.05). Cluster 2 (N = 37) had moderate freezing of gait scores (vs. cluster 1, P < 0.05), and motor function showed lower scores than cluster 3 (P < 0.05); however, the score was not significantly different from that of cluster 1 (P > 0.05). Cluster 3 had moderate freezing of gait scores (vs. cluster 1, P < 0.05; vs. 2, P > 0.05) and higher motor function scores than the other clusters (P < 0.05); however, the freezing of gait score was not significantly different from that of cluster 2 (P > 0.05).
CONCLUSIONS: This study revealed new subtypes that presents with freezing of gait but high motor function in patients with Parkinson's disease.