Life sciences · 2009
Antimicrobial properties of hemokinin-1 against strains of Pseudomonas aeruginosa.
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Berger Alexandra, Tran Anne H, Dedier Helen, Gardam Michael A, Paige Christopher J
Аннотация
AIMS: In this study, we examined whether hemokinin-1, the newest member of the tachykinin family and a close relative of substance P, has antimicrobial properties which have been attributed to other neuropeptides including substance P.
MAIN METHODS: Top agar assays were performed to determine the antimicrobial activity of hemokinin-1 and substance P against various microorganisms.
KEY FINDINGS: Here we provide evidence that hemokinin-1 peptide possesses antimicrobial properties against some strains of Pseudomonas aeruginosa, while substance P was only marginally effective.
SIGNIFICANCE: Our study is the first to link hemokinin-1 to the essential role of defending the body against microbial challenges and adds hemokinin-1 to the list of potential drugs that could help in the fight against P. aeruginosa, an opportunistic human pathogen.
MAIN METHODS: Top agar assays were performed to determine the antimicrobial activity of hemokinin-1 and substance P against various microorganisms.
KEY FINDINGS: Here we provide evidence that hemokinin-1 peptide possesses antimicrobial properties against some strains of Pseudomonas aeruginosa, while substance P was only marginally effective.
SIGNIFICANCE: Our study is the first to link hemokinin-1 to the essential role of defending the body against microbial challenges and adds hemokinin-1 to the list of potential drugs that could help in the fight against P. aeruginosa, an opportunistic human pathogen.