Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Gasparoto Antonio Luiz Dal Bello, Graeff Samara Vilas-Bôas, de Souza Santiago Wellyngton Matheus, da Silva Danielle Gomes, Dos Santos Thaynara Azevedo, Paulino Leandro Martin, Fava Wellington Santos, Reis Fernanda Paes, Stutz Claudia, de Oliveira França Adriana, Guerrero Moureau Ana Tereza Gomes, Montalbano Camila Amato, Lemos Everton Ferreira, Gonçalves Crhistinne Cavalheiro Maymone, Júnior Carlos Alberto Bento, Dallacqua Rodrigo Pires, Croda Julio, Lorenz Aline Pedroso, Souza Cristina, Martins Taynara Nogueira, da Silva Kassia Roberta Nogueira, Ferreira Alda Maria Teixeira, Negri Adriana Carla Garcia, Paniago Anamaria Mello Miranda, Motta-Castro Ana Rita Coimbra, Venturini James, da Costa Marques Ana Paula, do Valle Leone de Oliveira Sandra Maria
Аннотация
METHODS: From May 2020 to January 2021, 554 HCW directly involved with COVID-19 care were followed through 12 biweekly visits. During these visits, blood, nasal, and oropharyngeal samples were collected, and participants underwent interviews. SARS-CoV-2 detection was carried out using RT-qPCR, while the assessment of seroprevalence was based on IgG detection. Additionally, 35 positive samples underwent viral whole-genome sequencing.
RESULTS: The infection prevalence, as per RT-qPCR, was 28.5% (24.9-32.4), reflecting an overall attack rate ranging from 0.5% to 9.5%, marked by two peaks in August and December 2020. Oligosymptomatic and asymptomatic infections accounted for 14% of prevalent infections. The seroprevalence rate stood at 25.8%. The hospitalization rate was 8.2%, with a fatality rate of 1.3%. Risk factors associated with a positive diagnosis of COVID-19 included being male, working at the referral hospital, having a graduate-education level, and using hydroxychloroquine and zinc for prevention or treatment. One reinfection was identified. Absenteeism was 56.6%. The infection dynamics mirrored the pattern observed in the general population.
CONCLUSION: One-third of the professionals in the followed cohort were infected. Being male, working in a COVID-19 referral center, having a low level of education, and using medications for preventive treatment represented risk factors. Healthcare workers at the COVID-19 referral hospital exhibited a higher incidence rate compared to those at the non-referral hospital, increasing the plausibility that some of the infections occur in the hospital environment.