Journal of clinical gastroenterology · 2025
Association Between Indices of Thyroid Hormone Resistance and Constipation Prevalence in the US Population: NHANES 2007-2010.
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Li Cheng, Wu Ruozhen, Xie Diya
Аннотация
BACKGROUND: Chronic constipation is a common and complex condition that significantly impairs the quality of life and health care costs. Identifying the underlying cause is crucial for effective management, and hypothyroidism is frequently implicated. Nevertheless, extensive studies are scarce regarding this correlation. The research aims to examine the association between indices of thyroid hormone resistance, particularly the Thyroid Feedback Quantile-based Index of Free Thyroxine (TFQIFT4), and the occurrence of constipation among the population of the United States.
METHODS: The analysis examined data collected from 6354 participants in the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2010. Chronic constipation was determined as the Bristol Stool Form Scale (BSFS) types of 1 to 2 or <3 bowel movements weekly. Thyroid hormone resistance was assessed using various indices. The statistical analysis comprised weighted logistic regression, restricted cubic splines (RCS), subgroup analysis, and sensitivity analysis.
RESULTS: Chronic constipation was diagnosed in 10% of participants, displaying distinct characteristics. A nonlinear association between TFQIFT4 and constipation was observed, with inflection points at -0.25 and 0.376. Above a TFQIFT4 value of -0.25, a significantly negative association with constipation was found, primarily in females (OR=0.21; 95% CI: 0.10-0.44). No such association was found in males.
CONCLUSIONS: The study elucidates a complex correlation between thyroid hormone resistance, particularly TFQIFT4, and constipation. Gender-specific correlations were evident, with TFQIFT4 demonstrating a negative association with constipation, primarily in females. These findings underscore the need for further investigation into the underlying mechanisms involving central thyroid resistance and constipation across genders.
METHODS: The analysis examined data collected from 6354 participants in the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2010. Chronic constipation was determined as the Bristol Stool Form Scale (BSFS) types of 1 to 2 or <3 bowel movements weekly. Thyroid hormone resistance was assessed using various indices. The statistical analysis comprised weighted logistic regression, restricted cubic splines (RCS), subgroup analysis, and sensitivity analysis.
RESULTS: Chronic constipation was diagnosed in 10% of participants, displaying distinct characteristics. A nonlinear association between TFQIFT4 and constipation was observed, with inflection points at -0.25 and 0.376. Above a TFQIFT4 value of -0.25, a significantly negative association with constipation was found, primarily in females (OR=0.21; 95% CI: 0.10-0.44). No such association was found in males.
CONCLUSIONS: The study elucidates a complex correlation between thyroid hormone resistance, particularly TFQIFT4, and constipation. Gender-specific correlations were evident, with TFQIFT4 demonstrating a negative association with constipation, primarily in females. These findings underscore the need for further investigation into the underlying mechanisms involving central thyroid resistance and constipation across genders.