The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2010
Behcet's disease and heart transplantation: a word of caution.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Hollander Seth A, Yasnovsky Jessica R, Reinhartz Olaf, Chan Frandics, Sandborg Christy, Hunt Sharon, Bernstein Daniel, Chin Clifford
Аннотация
Behcet's disease is a rare autoimmune disease characterized by oral and genital ulcers, and by multisystem disease, including arthritis, neurologic complications and vasculitis. Large-vessel and coronary artery aneurysms are often an indication for surgery, but the return of aneurysms, thrombosis, and the tendency to exhibit an exaggerated inflammatory response at puncture sites (pathergy) complicate surgical recovery. As such, cardiac transplantation, which requires atrial and large-vessel anastomoses, has not been reported in patients with Behcet's disease. We report the first orthotopic heart transplant with >1-year survival in a patient with Behcet's disease despite major complications. The investigators remain pessimistic about cardiac transplantation in patients with Behcet's disease until advances in preventing recurrent vascular pathology ensue.