WMJ : official publication of the State Medical Society of Wisconsin · 2024
Human Parechovirus Infection in an Infant Presenting with Hyperferritinemia.
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McConnaha Kayla Rose, Bracken Zachary Kenneth, Mastey Rebecca Rose, Prakash Drew Koeppl, Prakash Pradeep Bangalore
Аннотация
INTRODUCTION: Human parechovirus (HPeV) is recognized as a cause of severe infections in infants.
CASE PRESENTATION: A 4-week-old febrile female with HPeV infection presented with persistent fevers and hyperferritinemia with normal C-reactive protein, suggestive of cytokine storm syndrome.
DISCUSSION: HPeV is known to cause encephalitis, hepatitis, sepsis, and organ dysfunction. However, few have documented hyperferritinemia and the role of cytokines in disease progression and the role of intravenous immunoglobulins (IVIG) used in the treatment of HPeV-induced hyperinflammation/cytokine storm.
CONCLUSIONS: HPeV infections in infants can present with hyperinflammation and sepsis-like syndrome. IVIG may have a role in the treatment of severe parechoviral infections in children who present with hyperferritinemia.
CASE PRESENTATION: A 4-week-old febrile female with HPeV infection presented with persistent fevers and hyperferritinemia with normal C-reactive protein, suggestive of cytokine storm syndrome.
DISCUSSION: HPeV is known to cause encephalitis, hepatitis, sepsis, and organ dysfunction. However, few have documented hyperferritinemia and the role of cytokines in disease progression and the role of intravenous immunoglobulins (IVIG) used in the treatment of HPeV-induced hyperinflammation/cytokine storm.
CONCLUSIONS: HPeV infections in infants can present with hyperinflammation and sepsis-like syndrome. IVIG may have a role in the treatment of severe parechoviral infections in children who present with hyperferritinemia.