Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry.
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Sokolski Mateusz, Trenson Sander, Sokolska Justyna M, D'Amario Domenico, Meyer Philippe, Poku Nana K, Biering-Sørensen Tor, Højbjerg Lassen Mats C, Skaarup Kristoffer G, Barge-Caballero Eduardo, Pouleur Anne-Catherine, Stolfo Davide, Sinagra Gianfranco, Ablasser Klemens, Muster Viktoria, Rainer Peter P, Wallner Markus, Chiodini Alessandra, Heiniger Pascal S, Mikulicic Fran, Schwaiger Judith, Winnik Stephan, Cakmak Huseyin A, Gaudenzi Margherita, Mapelli Massimo, Mattavelli Irene, Paul Matthias, Cabac-Pogorevici Irina, Bouleti Claire, Lilliu Marzia, Minoia Chiara, Dauw Jeroen, Costa Jérôme, Celik Ahmet, Mewton Nathan, Montenegro Carlos E L, Matsue Yuya, Loncar Goran, Marchel Michal, Bechlioulis Aris, Michalis Lampros, Dörr Marcus, Prihadi Edgard, Schoenrath Felix, Messroghli Daniel R, Mullens Wilfried, Lund Lars H, Rosano Giuseppe M C, Ponikowski Piotr, Ruschitzka Frank, Flammer Andreas J
Аннотация
METHODS AND RESULTS: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01-2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24-4.29], P < 0.001).
CONCLUSIONS: Hospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality.