Journal of the European Academy of Dermatology and Venereology : JEADV · 2021
Clinicopathological features of cutaneous reactions after mRNA-based COVID-19 vaccines.
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Tihy M, Menzinger S, André R, Laffitte E, Toutous-Trellu L, Kaya G
Аннотация
BACKGROUND: Cutaneous reactions, mostly on injection site after mRNA-based COVID-19 vaccines, have been reported but not with detailed histopathological characterization.
OBJECTIVES: Characterization and classification of these reactions in a clinical and pathological point of view.
METHODS: Monocentric case series of 11 patients with cutaneous manifestations, clinically and histologically characterized after COVID-19 vaccination.
RESULTS: From January to June 2021, we recorded 11 cutaneous reactions to mRNA COVID-19 vaccines from BNT162b2 (n = 8) and mRNA-1273 (n = 3). Generalized reactions showing erythematous rash or purpura were the most common clinical presentation, and drug-reaction-like pattern was the most common histological finding.
CONCLUSIONS: A proper clinicopathological classification will be helpful in the early diagnosis and management of the cutaneous reactions to mRNA COVID-19 vaccines.
OBJECTIVES: Characterization and classification of these reactions in a clinical and pathological point of view.
METHODS: Monocentric case series of 11 patients with cutaneous manifestations, clinically and histologically characterized after COVID-19 vaccination.
RESULTS: From January to June 2021, we recorded 11 cutaneous reactions to mRNA COVID-19 vaccines from BNT162b2 (n = 8) and mRNA-1273 (n = 3). Generalized reactions showing erythematous rash or purpura were the most common clinical presentation, and drug-reaction-like pattern was the most common histological finding.
CONCLUSIONS: A proper clinicopathological classification will be helpful in the early diagnosis and management of the cutaneous reactions to mRNA COVID-19 vaccines.