Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2011
[Correlation between serum growth differentiation factor-15 and TIMI risk scores in patients with unstable angina pectoris].
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Deng Ming-yao, Wu Guo-ping, Feng Xu-xia, Luo Jiang-bin
Аннотация
OBJECTIVE: To explore the correlation between serum levels of growth differentiation factor-15 (GDF-15) and Thrombolysis in Myocardial Infarction (TIMI) risk scores in patients with unstable angina pectoris (UA).
METHODS: The serum levels of GDF-15 in 97 patients with UA and 30 healthy volunteers were measured using enzyme-linked immunosorbent assay (ELISA) and compared between 3 patient groups with different TIMI scores to analyze relationship between serum GDF-15 levels and TIMI risk scores.
RESULTS: The serum levels of GDF-15 in UA patients were significantly higher than those in the healthy volunteers (P<0.01). GDF-15 levels also differed significantly between patients with different TIMI scores (P<0.01), and showed a significant positive correlation to TIMI risk scores.
CONCLUSION: Serum levels of GDF-15 can be used as an index for evaluating the severity of UA.
METHODS: The serum levels of GDF-15 in 97 patients with UA and 30 healthy volunteers were measured using enzyme-linked immunosorbent assay (ELISA) and compared between 3 patient groups with different TIMI scores to analyze relationship between serum GDF-15 levels and TIMI risk scores.
RESULTS: The serum levels of GDF-15 in UA patients were significantly higher than those in the healthy volunteers (P<0.01). GDF-15 levels also differed significantly between patients with different TIMI scores (P<0.01), and showed a significant positive correlation to TIMI risk scores.
CONCLUSION: Serum levels of GDF-15 can be used as an index for evaluating the severity of UA.