Clinical biochemistry · 2011
Role of advanced oxidation protein products and Thiol ratio in patients with acute coronary syndromes.
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Barsotti Antonio, Fabbi Patrizia, Fedele Massimiliano, Garibaldi Silvano, Balbi Manrico, Bezante Gian Paolo, Risso Domenico, Indiveri Francesco, Ghigliotti Giorgio, Brunelli Claudio
Аннотация
OBJECTIVES: To identify systemically detectable vascular inflammation associated to redox system unbalance, advanced oxidation protein products (AOPP), formed by HClO reaction with proteins, Thiol levels, and their ratio (AOPP/Thiol ratio) were measured in patients with acute coronary syndromes (ACS).
DESIGN AND METHODS: We evaluated AOPP/Thiol ratio together with CRP and IL-1β in 18 acute myocardial infarction (AMI) and in 16 unstable angina (UA) patients at admission, and in 16 control subjects (CTR); the measurements were repeated at 1 and at 6 months.
RESULTS: At admission, AMI and UA patients displayed higher AOPP/Thiol ratio and CRP and IL-1β compared to CTR subjects. A correlation between AOPP/Thiols and IL-1β in AMI was found. At follow-up, in UA only, AOPP/Thiol ratio and IL-1β levels still remained high.
CONCLUSIONS: The AOPP/Thiol ratio seems to affect the inflammatory process in ACS, and may represent a reliable marker of oxidative unbalance in this setting of patients.
DESIGN AND METHODS: We evaluated AOPP/Thiol ratio together with CRP and IL-1β in 18 acute myocardial infarction (AMI) and in 16 unstable angina (UA) patients at admission, and in 16 control subjects (CTR); the measurements were repeated at 1 and at 6 months.
RESULTS: At admission, AMI and UA patients displayed higher AOPP/Thiol ratio and CRP and IL-1β compared to CTR subjects. A correlation between AOPP/Thiols and IL-1β in AMI was found. At follow-up, in UA only, AOPP/Thiol ratio and IL-1β levels still remained high.
CONCLUSIONS: The AOPP/Thiol ratio seems to affect the inflammatory process in ACS, and may represent a reliable marker of oxidative unbalance in this setting of patients.