Addictive behaviors · 2015
Cognitive performance in a placebo-controlled pharmacotherapy trial for youth with marijuana dependence.
СтатьяРандомизированное исследованиеПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Roten Amanda, Baker Nathaniel L, Gray Kevin M
Аннотация
BACKGROUND: Adolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance.
METHODS: This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery.
RESULTS: Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores.
CONCLUSIONS: These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.
METHODS: This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery.
RESULTS: Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores.
CONCLUSIONS: These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.