Percutaneous repair or medical treatment for secondary mitral regurgitation: outcomes at 2 years.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Iung Bernard, Armoiry Xavier, Vahanian Alec, Boutitie Florent, Mewton Nathan, Trochu Jean-Noël, Lefèvre Thierry, Messika-Zeitoun David, Guerin Patrice, Cormier Bertrand, Brochet Eric, Thibault Hélène, Himbert Dominique, Thivolet Sophie, Leurent Guillaume, Bonnet Guillaume, Donal Erwan, Piriou Nicolas, Piot Christophe, Habib Gilbert, Rouleau Frédéric, Carrié Didier, Nejjari Mohammed, Ohlmann Patrick, Saint Etienne Christophe, Leroux Lionel, Gilard Martine, Samson Géraldine, Rioufol Gilles, Maucort-Boulch Delphine, Obadia Jean François, MITRA-FR Investigators
Аннотация
METHODS AND RESULTS: At 37 centres, we randomly assigned 304 symptomatic heart failure patients with severe secondary mitral regurgitation (effective regurgitant orifice area >20 mm2 or regurgitant volume >30 mL), and left ventricular ejection fraction between 15% and 40% to undergo percutaneous valve repair plus medical treatment (intervention group, n = 152) or medical treatment alone (control group, n = 152). The primary efficacy outcome was the composite of all-cause death and unplanned hospitalization for heart failure at 12 months. At 24 months, all-cause death and unplanned hospitalization for heart failure occurred in 63.8% of patients (97/152) in the intervention group and 67.1% (102/152) in the control group [hazard ratio (HR) 1.01, 95% confidence interval (CI) 0.77-1.34]. All-cause mortality occurred in 34.9% of patients (53/152) in the intervention group and 34.2% (52/152) in the control group (HR 1.02, 95% CI 0.70-1.50). Unplanned hospitalization for heart failure occurred in 55.9% of patients (85/152) in the intervention group and 61.8% (94/152) in the control group (HR 0.97, 95% CI 0.72-1.30).
CONCLUSIONS: In patients with severe secondary mitral regurgitation, percutaneous repair added to medical treatment did not significantly reduce the risk of death or hospitalization for heart failure at 2 years compared with medical treatment alone.