[Significance of subcutaneous nodules in the leg for the diagnosis of connective tissue pathology in patients with cardiovascular diseases].

Subcutaneous nodules on the leg were found in 40 (16%) of 250 male cardiologic in-patients, aged 17-65; they correlated, with a significant frequency with increased skin distensibility, overextension of the fingers and breast-bone deformation, mitral valve prolapse and atrial fibrillation. This feature can be used in the diagnosis of inherited generalized connective-tissue dysplasia.