THE CORRELATION BETWEEN INFLAMMATORY AND METABOLIC PARAMETERS WITH THYROID FUNCTION IN PATIENTS WITH HASHIMOTO'S THYROIDITIS: THE POTENTIAL ROLE OF INTERLEUKIN 23 (IL-23) AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) - 1.

CONTEXT: Hashimoto's thyroiditis is the most common autoimmune disorder as cause of secondary hypothyroidism. The disease is associated with several metabolic disturbances and inflammatory disorders.

OBJECTIVES

The aim of the current report was to evaluate several inflammatory and metabolic predictors of Hashimoto's thyroiditis.

SUBJECTS AND

METHODS

In the current study, forty patients with Hashimoto's thyroiditis participated in the current study. They were aged between 20 to 50 years old. Anthropometric and nutritional measurements were assessed and biochemical factors including serum VEGF, IL-23, Nesfatin-1 and serum lipids were measured.

RESULTS

Waist circumference was higher among patients with lower serum TSH concentrations. Serum HDL and T4 concentrations were lower and serum IL-23 was higher among patients with higher TSH concentrations. BMI, WC and serum HDL were negative predictors of serum TSH while IL-23 was positively associated with TSH concentrations. Serum lipids including TC, TG and LDL were also negatively associated with T3 and T4 concentrations.

CONCLUSIONS

According to our findings, VEGF and serum IL-23 were potent predictors of Hashimoto's thyroiditis. However, further studies are warranted to better clarify these associations and underlying pathologic mechanisms.