Science (New York, N.Y.) · 2024
Evolution and host-specific adaptation of Pseudomonas aeruginosa.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Weimann Aaron, Dinan Adam M, Ruis Christopher, Bernut Audrey, Pont Stéphane, Brown Karen, Ryan Judy, Santos Lúcia, Ellison Louise, Ukor Emem, Pandurangan Arun P, Krokowski Sina, Blundell Tom L, Welch Martin, Blane Beth, Judge Kim, Bousfield Rachel, Brown Nicholas, Bryant Josephine M, Kukavica-Ibrulj Irena, Rampioni Giordano, Leoni Livia, Harrison Patrick T, Peacock Sharon J, Thomson Nicholas R, Gauthier Jeff, Fothergill Jo L, Levesque Roger C, Parkhill Julian, Floto R Andres
Аннотация
The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF). We show that a few environmental isolates, driven by horizontal gene acquisition, have become dominant epidemic clones that have sequentially emerged and spread through global transmission networks over the past 200 years. These clones demonstrate varying intrinsic propensities for infecting CF or non-CF individuals (linked to specific transcriptional changes enabling survival within macrophages); have undergone multiple rounds of convergent, host-specific adaptation; and have eventually lost their ability to transmit between different patient groups. Our findings thus explain the pathogenic evolution of P. aeruginosa and highlight the importance of global surveillance and cross-infection prevention in averting the emergence of future epidemic clones.