The British journal of psychiatry : the journal of mental science · 1995
Neuroleptic associated tardive dyskinesias in young people with psychoses.
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Pourcher E, Baruch P, Bouchard R H, Filteau M J, Bergeron D
Аннотация
BACKGROUND: Apart from ageing, the factors associated with vulnerability to the emergence of tardive dyskinesia are poorly defined.
METHOD: Risk factors associated with the presence of a chronic choreic or dystonic disorder were assessed in a cross-sectional comparison of anamnestic and clinical data in a homogeneous group of 64 young psychotic patients (under 40 years of age) on chronic low to moderate doses of neuroleptics.
RESULTS: Dyskinetic subjects presented more indirect indicators of occult brain damage, such as a perinatal event or traumatic brain injuries in infancy and early childhood; neurological examination showed more anomalies in dyskinetic patients than in nondyskinetics, with a higher prevalence of facial release reflexes.
CONCLUSION: These data may support the hypothesis that occult acquired brain damage is important in the genesis of this 'drug-induced' disorder.
METHOD: Risk factors associated with the presence of a chronic choreic or dystonic disorder were assessed in a cross-sectional comparison of anamnestic and clinical data in a homogeneous group of 64 young psychotic patients (under 40 years of age) on chronic low to moderate doses of neuroleptics.
RESULTS: Dyskinetic subjects presented more indirect indicators of occult brain damage, such as a perinatal event or traumatic brain injuries in infancy and early childhood; neurological examination showed more anomalies in dyskinetic patients than in nondyskinetics, with a higher prevalence of facial release reflexes.
CONCLUSION: These data may support the hypothesis that occult acquired brain damage is important in the genesis of this 'drug-induced' disorder.