Hepato-gastroenterology · 2013
Histological complete response after neoadjuvant XELOX in advanced gastric carcinoma.
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Zhao Qun, Li Yong, Tian Yuan, Chen Yan-Ning, Tan Bi-Bo, Zhao Xüe-Feng, Jiao Zhi-Kai, Zhang Zhi-Dong, Chang Sheng-Li
Аннотация
We report on a case of a 65-year-old Chinese male with locally advanced gastric adenocarcinoma achieving pathological complete response after neoadjuvant chemotherapy with capecitabine and oxaliplatin (XELOX) regimen. He underwent esophagogastroduodenoscopy, which revealed a 6x5cm gastric ulcer. Biopsy of gastric ulcer revealed adenocarcinoma. Further workups with abdominal enhancement computed tomography (CT) staged his cancer as T4N2M0. He received 2 cycles of neoadjuvant chemotherapy with XELOX without severe toxicity. Afterwards, he underwent curative surgery consisting of total gastrectomy with extended D2 lymph node dissections and a Roux-en-Y esophagojejunostomy. On microscopic examination, no tumor cells were detected in the ulcer scar of the resected stomach and in the regional lymph nodes. The benefit of XELOX regimen as neoadjuvant chemotherapy in gastric cancer is worth further investigation.
Предметные рубрики MeSH
AdenocarcinomaAgedAnastomosis, Roux-en-YAntineoplastic Combined Chemotherapy ProtocolsBiopsyCapecitabineDeoxycytidineEndoscopy, Digestive SystemEsophagostomyFluorouracilGastrectomyHumansLymph Node ExcisionMaleNeoadjuvant TherapyNeoplasm StagingOxaloacetatesStomach NeoplasmsTomography, X-Ray ComputedTreatment Outcome