Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2012
Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Amaral Guilherme Pires, de Carvalho Nelson Rodrigues, Barcelos Rômulo Pillon, Dobrachinski Fernando, Portella Rafael de Lima, da Silva Michele Hinerasky, Lugokenski Thiago Henrique, Dias Glaecir Roseni Mundstock, da Luz Sônia Cristina Almeida, Boligon Aline Augusti, Athayde Margareth Linde, Villetti Marcos Antonio, Antunes Soares Félix Alexandre, Fachinetto Roselei
Аннотация
The pathology of a gastric ulcer is complex and multifactorial. Gastric ulcers affect many people around the world and its development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. In this study, we evaluated the ethanolic extract of Rosmarinus officinalis L. (eeRo); this plant, more commonly known as rosemary, has attracted the interest of the scientific community due to its numerous pharmacological properties and their potential therapeutic applications. Here, we tested the preventive effects of eeRo against gastric ulcer induced by 70% ethanol in male Wistar rats. In addition, we aimed to clarify the mechanism involved in the preventive action of the eeRo in gastric ulcers. Based on the analysis of markers of oxidative damage and enzymatic antioxidant defense systems, the measurement of nitrite and nitrate levels and the assessment of the inflammatory response, the eeRo exhibited significant antioxidant, vasodilator and antiinflammatory properties.