Proceedings of the National Academy of Sciences of the United States of America · 2017
MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Lin Quan, Ponnusamy Ravikumar, Widagdo Jocelyn, Choi Jung A, Ge Weihong, Probst Christine, Buckley Tyler, Lou Mimi, Bredy Timothy W, Fanselow Michael S, Ye Keqiang, Sun Yi E
Аннотация
The prenatal period of cortical development is important for the establishment of neural circuitry and functional connectivity of the brain; however, the molecular mechanisms underlying this process remain unclear. Here we report that disruption of the actin-cytoskeletal network in the developing mouse prefrontal cortex alters dendritic morphogenesis and synapse formation, leading to enhanced formation of fear-related memory in adulthood. These effects are mediated by a brain-enriched microRNA, miR-9, through its negative regulation of diaphanous homologous protein 1 (Diap1), a key organizer of the actin cytoskeletal assembly. Our findings not only revealed important regulation of dendritogenesis and synaptogenesis during early brain development but also demonstrated a tight link between these early developmental events and cognitive functions later in life.