Epigenomics · 2016
Association of aberrant methylation at promoter regions of tumor suppressor genes with placental pathologies.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rahat Beenish, Thakur Shilpa, Hamid Abid, Bagga Rashmi, Kaur Jyotdeep
Аннотация
AIM: The resemblance between invasive behavior of cancer cells and placental trophoblasts and the role of aberrant epigenetic regulation in cancer development is well known.
METHODS: We analyzed the role of promoter region CpG-methylation and H3K9/27me3 of tumor suppressor genes in normal and pathological pregnancies and utilized their CpG-methylation data to search for fetal DNA epigenetic marker in maternal blood.
RESULTS: CpG and H3K9/27-methylation associated decreased expression of RASSF1A and APC and increased expression of P16, RB1 and PRKCDBP was observed with advancing normal gestation. Gestational trophoblastic diseases and preeclampsia revealed gene-specific epigenetic deregulation of candidate tumor suppressor genes. Furthermore, APC and PRKCDBP showed the potential to act as fetal DNA epigenetic markers, similar to RASSF1A.
CONCLUSION: Deregulation of methylation of tumor suppressor genes contributes to the development of preeclampsia and gestational trophoblastic diseases. APC and PRKCDBP may act as fetal DNA epigenetic markers for prenatal diagnosis.
METHODS: We analyzed the role of promoter region CpG-methylation and H3K9/27me3 of tumor suppressor genes in normal and pathological pregnancies and utilized their CpG-methylation data to search for fetal DNA epigenetic marker in maternal blood.
RESULTS: CpG and H3K9/27-methylation associated decreased expression of RASSF1A and APC and increased expression of P16, RB1 and PRKCDBP was observed with advancing normal gestation. Gestational trophoblastic diseases and preeclampsia revealed gene-specific epigenetic deregulation of candidate tumor suppressor genes. Furthermore, APC and PRKCDBP showed the potential to act as fetal DNA epigenetic markers, similar to RASSF1A.
CONCLUSION: Deregulation of methylation of tumor suppressor genes contributes to the development of preeclampsia and gestational trophoblastic diseases. APC and PRKCDBP may act as fetal DNA epigenetic markers for prenatal diagnosis.
Предметные рубрики MeSH
Adenomatous Polyposis Coli ProteinAdultBiomarkersCell LineCpG IslandsCyclin-Dependent Kinase Inhibitor p16DNA MethylationEpigenesis, GeneticFemaleGenes, Tumor SuppressorGestational Trophoblastic DiseaseHistonesHumansIntracellular Signaling Peptides and ProteinsPlacentaPre-EclampsiaPregnancyPromoter Regions, GeneticProtein Processing, Post-TranslationalRetinoblastoma Binding ProteinsTranscriptomeTumor Suppressor ProteinsUbiquitin-Protein LigasesYoung Adult