Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2026
Comparing the risk of ocular inflammation secondary to sarcoidosis between non-Hispanic White population and Black/African American population.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Reddy Manisha, Randolph Jessica
Аннотация
OBJECTIVE: To assess the risk of developing ocular inflammation in the setting of sarcoidosis among non-Hispanic White (NHW) and Black/African American populations (BAA).
DESIGN: Retrospective, population-based cohort study PARTICIPANTS: Participants were aged ≥18 years, diagnosed with sarcoidosis in the last 10 years, and divided into 2 cohorts of NHW and BAA descent. Propensity score matching was used to match for age and sex.
METHODS: Using the TriNetX database, we determined the frequency of anterior uveitis, chorioretinal inflammation (CRI), optic neuritis (ON), and other disorders of the optic disc between the 2 cohorts using International Classification of Diseases, Tenth Revision, codes. Alternatively, the incidence of sarcoidosis was examined in patients diagnosed with ocular inflammation in the last 10 years, with sarcoidosis diagnosis occurring within 3 months after ocular inflammation.
MAIN OUTCOME MEASURES: Risk ratio of the incidence of ocular inflammation between NHW and BAA populations, and the odds ratio of being diagnosed with sarcoidosis when presenting with ocular inflammation between NHW and BAA populations.
RESULTS: After propensity score matching, each sarcoidosis cohort had 39 604 patients (mean age of 54.6 (± 13.4) years). Incidence of anterior uveitis was 1188 (3%) NHW and 1868 (4.7%) BAA with RR 0.636 (P < .0001, confidence interval [CI] 0.592-0.683). The incidence of CRI was 410 (1.0%) NHW and 309 (0.8%) BAA with RR 1.327 (P = .0002, CI 1.145-1.537). Incidence of ON was 538 (1.4%) NHW and 660 (1.7%) BAA with RR 0.815 (P = .0004, CI 0.728-0.913). Each anterior uveitis cohort had 32 780 patients (mean age 48.4 ± 18.3 years). Sarcoidosis was identified in 507 (1.5%) NHW and 1103 (3.4%) BAA with OR 0.451 (P < .0001, CI 0.406-0.502). Each CRI cohort had 4116 patients (mean age of 49.8 ± 17.7). Sarcoidosis was identified in 77 (1.9%) NHW and 190 (4.6%) BAA with OR 0.394 (P < .0001, CI 0.301-0.515). Each ON cohort had 22971 patients (mean age of 49.2 ± 17.9). Sarcoidosis was identified in 141 (0.6%) NHW and 483 (2.1%) BAA with OR 0.288 (P < .0001, CI 0.238-0.347).
CONCLUSIONS: In those with sarcoidosis, BAA are at increased risk of developing anterior uveitis and optic neuropathy, while NHW are at increased risk of developing chorioretinal inflammation. BAA patients newly diagnosed with ocular inflammation are more likely to be diagnosed with sarcoidosis compared to their NHW counterparts.
DESIGN: Retrospective, population-based cohort study PARTICIPANTS: Participants were aged ≥18 years, diagnosed with sarcoidosis in the last 10 years, and divided into 2 cohorts of NHW and BAA descent. Propensity score matching was used to match for age and sex.
METHODS: Using the TriNetX database, we determined the frequency of anterior uveitis, chorioretinal inflammation (CRI), optic neuritis (ON), and other disorders of the optic disc between the 2 cohorts using International Classification of Diseases, Tenth Revision, codes. Alternatively, the incidence of sarcoidosis was examined in patients diagnosed with ocular inflammation in the last 10 years, with sarcoidosis diagnosis occurring within 3 months after ocular inflammation.
MAIN OUTCOME MEASURES: Risk ratio of the incidence of ocular inflammation between NHW and BAA populations, and the odds ratio of being diagnosed with sarcoidosis when presenting with ocular inflammation between NHW and BAA populations.
RESULTS: After propensity score matching, each sarcoidosis cohort had 39 604 patients (mean age of 54.6 (± 13.4) years). Incidence of anterior uveitis was 1188 (3%) NHW and 1868 (4.7%) BAA with RR 0.636 (P < .0001, confidence interval [CI] 0.592-0.683). The incidence of CRI was 410 (1.0%) NHW and 309 (0.8%) BAA with RR 1.327 (P = .0002, CI 1.145-1.537). Incidence of ON was 538 (1.4%) NHW and 660 (1.7%) BAA with RR 0.815 (P = .0004, CI 0.728-0.913). Each anterior uveitis cohort had 32 780 patients (mean age 48.4 ± 18.3 years). Sarcoidosis was identified in 507 (1.5%) NHW and 1103 (3.4%) BAA with OR 0.451 (P < .0001, CI 0.406-0.502). Each CRI cohort had 4116 patients (mean age of 49.8 ± 17.7). Sarcoidosis was identified in 77 (1.9%) NHW and 190 (4.6%) BAA with OR 0.394 (P < .0001, CI 0.301-0.515). Each ON cohort had 22971 patients (mean age of 49.2 ± 17.9). Sarcoidosis was identified in 141 (0.6%) NHW and 483 (2.1%) BAA with OR 0.288 (P < .0001, CI 0.238-0.347).
CONCLUSIONS: In those with sarcoidosis, BAA are at increased risk of developing anterior uveitis and optic neuropathy, while NHW are at increased risk of developing chorioretinal inflammation. BAA patients newly diagnosed with ocular inflammation are more likely to be diagnosed with sarcoidosis compared to their NHW counterparts.