[The part of the hormone-cyclase system in achieving the therapeutic effect of hydrochloric acid secretion inhibitors at the duodenal ulcer].

There was a study of changes in blood hormone levels (gastrin, insulin, cortisol) and cyclic nucleotides (cAMPh, cGMPh) in the treatment of 120 patients with duodenal ulcer with anti-secretion drugs of different mechanisms of action. Changes in hormone and cyclic nucleotide levels were discovered both directly after the administration of anti-secretion drugs and after a course of treatment with them. The data obtained increase the knowledge about the mechanisms of anti-secretion drugs action and their influence on the stomach secretion function at the duodenal ulcer.