Terapevticheskii arkhiv · 2006
[Quality of life in patients with duodenal ulcer].
Сравнительное исследованиеАннотация на английскомСтатьяНазвание и аннотация: Оригинал на русском
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Guseĭndzade M G
Аннотация
AIM: To examine influence of duodenal ulcer (DU) on quality of life (QL) and changes in QL after different DU treatments.
MATERIAL AND METHODS: QL in DU was assessed with Russian version of SF-36 questionnaire in 66 DUpatients with Helicobacter pylori (HP) aged 16-80 years (mean age 44.6 +/- 17.3 years).
RESULTS: DU healing was achieved after 2 weeks of therapy with ranitidine (300 mg/day), amoxicilline (2000 mg/day), metronidasole (1000 mg/day), and famotidin (40 mg/day), amoxicilline (2000 mg/day, clarithromycin (1000 mg/day) in 69.2 and 94.9% cases (p = 0.04), after 4 weeks--88.2 and 96.8%, rrespectively (p = 0.52). Hospital stay was 16.1 +/- 2.1 and 22.2 +/- 3.4 (p < 0.05), respectively. Exacerbation of DU leads to deterioration of QL according to all the SF-36 scales. Four weeks of therapy produced a statistically significant (p < 0.05) improvement of QL by all the scales. In failure of HP eradication QL worsened.
CONCLUSION: QL is low in exacerbation of DU associated with HP. Antihelicobacter therapy improves QL of DUpatients. QL investigations help to select most effective therapy.
MATERIAL AND METHODS: QL in DU was assessed with Russian version of SF-36 questionnaire in 66 DUpatients with Helicobacter pylori (HP) aged 16-80 years (mean age 44.6 +/- 17.3 years).
RESULTS: DU healing was achieved after 2 weeks of therapy with ranitidine (300 mg/day), amoxicilline (2000 mg/day), metronidasole (1000 mg/day), and famotidin (40 mg/day), amoxicilline (2000 mg/day, clarithromycin (1000 mg/day) in 69.2 and 94.9% cases (p = 0.04), after 4 weeks--88.2 and 96.8%, rrespectively (p = 0.52). Hospital stay was 16.1 +/- 2.1 and 22.2 +/- 3.4 (p < 0.05), respectively. Exacerbation of DU leads to deterioration of QL according to all the SF-36 scales. Four weeks of therapy produced a statistically significant (p < 0.05) improvement of QL by all the scales. In failure of HP eradication QL worsened.
CONCLUSION: QL is low in exacerbation of DU associated with HP. Antihelicobacter therapy improves QL of DUpatients. QL investigations help to select most effective therapy.