Terapevticheskii arkhiv · 2006
[Complex evaluation of the action of inhibitors of hydrochloric acid secretion on gastric function in ulcer disease].
Сравнительное исследованиеСтатьяНазвание и аннотация: Оригинал на русском
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Vakhrushev Ia M, Muravtseva O V
Аннотация
AIM: To characterize actions of inhibitors of hydrochloric acid secretion on gastric function and to formulate indications to using different antisecretory drugs in ulcer disease (UD).
MATERIAL AND METHODS: Of 120 examinees with duodenal ulcer (DU), 40 received gastrocepin, 40--famotidin, 40--omeprasol. Follow-up study was made of motor, acid-, pepsin- and mucus-forming functions of the stomach.
RESULTS: By reducing production of acid and pepsin, gastrocepin is inferior to famotidin and omeprasol. Gastrocepin is more effective than famotidin and omeprasol in motor-evacuatory dysfunction. Gastrocepin improves defensive properties of gastric mucus better.
CONCLUSION: The results expand indications for a differential administration of antisecretory drugs in UD.
MATERIAL AND METHODS: Of 120 examinees with duodenal ulcer (DU), 40 received gastrocepin, 40--famotidin, 40--omeprasol. Follow-up study was made of motor, acid-, pepsin- and mucus-forming functions of the stomach.
RESULTS: By reducing production of acid and pepsin, gastrocepin is inferior to famotidin and omeprasol. Gastrocepin is more effective than famotidin and omeprasol in motor-evacuatory dysfunction. Gastrocepin improves defensive properties of gastric mucus better.
CONCLUSION: The results expand indications for a differential administration of antisecretory drugs in UD.