[Complex evaluation of the action of inhibitors of hydrochloric acid secretion on gastric function in ulcer disease].

AIM: To characterize actions of inhibitors of hydrochloric acid secretion on gastric function and to formulate indications to using different antisecretory drugs in ulcer disease (UD).

MATERIAL AND

METHODS

Of 120 examinees with duodenal ulcer (DU), 40 received gastrocepin, 40--famotidin, 40--omeprasol. Follow-up study was made of motor, acid-, pepsin- and mucus-forming functions of the stomach.

RESULTS

By reducing production of acid and pepsin, gastrocepin is inferior to famotidin and omeprasol. Gastrocepin is more effective than famotidin and omeprasol in motor-evacuatory dysfunction. Gastrocepin improves defensive properties of gastric mucus better.

CONCLUSION

The results expand indications for a differential administration of antisecretory drugs in UD.