[Changes in the content of insoluble glycoproteins in the mucous barrier of the stomach as a diagnostic criterion for assessment of the severity of the duodenal ulcer associated with Helicobacter infection].

The study examined the interrelation of changes in the protective mucous barrier of the stomach depending on the severity of the ulcer course in a comparative aspect in patients with duodenal ulcer associated with Helicobacter pylori (HP) and without it. It was established that disorders of the mucous barrier in the gastroduodenal zone are caused by a lack of the main component--fucose in patients with associated HP. Changes in the fucose content in the mucous gel of gastric juice depending on the disease severity may be used as a diagnostic criterion. An even and less considerable reduction of the content of insoluble glycoproteins fractions in the mucous gel of gastric juice is characteristic of the patients without associated HP and these changes do not determine the disease severity.