Nitric oxide : biology and chemistry · 2004
NO-dependent phototoxicity of Roussin's black salt against cancer cells.
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Janczyk Agnieszka, Wolnicka-Glubisz Agnieszka, Chmura Antonina, Elas Martyna, Matuszak Zenon, Stochel Grazyna, Urbanska Krystyna
Аннотация
A metal-nitrosyl complex, Roussin's black salt (RBS), releases nitric oxide after illumination. Approximately 3.7 NO molecules were released from one RBS molecule. Both short- and long-term effects of photogenerated NO on the two neoplastic cell lines: human (SK-MEL188) and mouse (S91) have been investigated. Exogenous NO from RBS was toxic to cells in a dose-dependent manner. Apoptotic damage predominates in the response to the injury, as shown by TUNEL assay. NO and its short-lived metabolites, but not other RBS photoproducts, are responsible for cellular death. RBS in dark was toxic to cells at concentrations above 1 microM. This relatively high cytotoxicity of RBS in the dark prevents its application as a systemic anticancer agent in vivo, unless it is applied locally.